Voxtalisib (SAR245409)

Name	SAR245409
Synonyms	CS-1242 SAR245409 Voxtalisib VOXTALISIB Voxtalisib (XL-765) Voxtalisib (SAR245409) Voxtalisib (XL765, SAR245409) SAR245409 (XL765, Voxtalisib) Voxtalisib (SAR245409, XL765) Analogue 2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one
CAS	934493-76-2

Molecular Formula	C13H14N6O
Molar Mass	270.29
Density	1.397±0.06 g/cm3(Predicted)
Boling Point	605.0±65.0 °C(Predicted)
Solubility	DMSO: 16 mg/mL
pKa	12.54±0.10(Predicted)
Storage Condition	-20℃
In vitro study	XL765 was the first oral dual inhibitor of PI3K and mTOR, with IC50 values of 39, 113, 9, 43, and -150 nM for p110α, β, γ, δ, and mTOR, respectively. In vitro, XL765 reduced cell viability in a concentration-dependent manner.
In vivo study	Oral feeding of XL765 resulted in a 12-fold decrease in metaphase tumors compared to the control group. XL765 showed activity either alone or in combination with other drugs in various GBM xenografts. XL765 acts on in vitro cultured human xenografts, resulting in down-regulation of the downstream phosphorylated proteins of PI3K: pAkt and pPRAS40, and the downstream phosphorylated proteins of mTOR: pS6 and p4EBP1.

HS Code

29337900

Last Update：2024-01-02 23:10:35

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CAS: 934493-76-2
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Email: 3008007409@qq.com
Mobile: 18021002903
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Voxtalisib (SAR245409)

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